Modern Zoology, The Genetics and Transgenics
1). Neuro-endocrine signalling & cytogenesis,
2). Transgenic trape & gene program expression,
3). Pharmaceutic effects & genetic controlling,
4). Embryo culture & stem cell differentiation.
2006-present (President, Institute of Systems Biological Engineering, China): Systems Genetics & Synthetic Biology.
Applied systems genetics in biological engineering - transgenic bioreactor & cellular biocomputer etc.
1997-2006 (TelAviv Univ., FAL Institute, Birmingham Univ. Israel, Germany & UK): Signal Transduction & Gene Regulated Expression.
Isolating of genes, cell lines and characterizing of signal transduction
pathways involved in cell fate determination, differentiation and apoptosis (Pattern Genetics: Non-linear Cell Dynamics, March 2002).
1994-1997 (Instituteof Microbiology, CAS, China): Gene Recombination, Genetics of Ageing & Transgenesis.
Pharmaceutical effects on ageing, the system (structure/pattern) genetics and
transgenic chicken: the ovarian duct expression system
(On the concept of system biological engineering, Transgenic avian - oviduct bioreactor for gold egg,
Structure/system/pattern genetics and transgenic animals,
Communication on Transgenic Animals, CAS, China, No. 6, 11, 12, 1994).
1985-1994 (Collegies of Agriculture, Medicine, China): Pharmacognacy, Psychosomatic Medicine & Cytogenetics.
Pharmacognacy involved in memory function, the patterns and rhythm Stability of the
Main and Collateral Channels (TCM) in morphogenesis (Structurity: the Pan-Evolution Theory, May 1994).
.Secretary-General, 1st International Conference on Transgenic Animals (ICTA), Beijing, 1996.
.Secretary-General, the (World) Associates for Biosystem Science and Engineering (WABSE 1999, includes the International Union of Transgenics - IUT 1997 etc.).
.Permanent member, Chinese Biotechnology Society since July 1996.
.Deputy Secretary-General, Chinese Association on Transgenic Animals, 1994 to 1998.
.Member of editorial board, the Journal of Sheng Wu Ji Su Tong Bao (Biotechnology), since Jan. 1997, China.
.Member of editors board, Communication on Transgenic Animals, Oct. 1994 to Dec. 1998, China.
.Ph.D. scholarship, DFG scientist, RF & SPARKS grant-holder, 1997 to 2006, Israel & Europe.
.Awarded the Excellent Researcher in Medicine for Decade (due to articles on Systems Medicine), Hunan China, 1992.
.Graduated from Xiamen University, BSc. of Animal Cytogenetics, China, 1985.
The molecular synthesis between degradation, and cell prolification
between apotosis are controlled by neuro-endocrine signaling and gene expression. On the cascades of
interacting regulatory in gene expression, the commitment factors, transcription factors which mediate the
phenotypic expression of different cell types, receptors, intercellular signals and cell-adhesion molecules,
they act on some cells very early and during a limited period of time. The major
groups of transcription factors have been classified according to the motif in the DNA-binding domains.
Interestingly, many transcription factors activate or repress their own expression and thus
constitute the autoregulatory feedback loops which function as molecular clock. These factors
regulate the cell cycle and cell specifical fate determination in morphogenesis of organism. In oocyte,
cellular factors can reboot somatic nuclei genetic reprogram and maintain ES cell in totipotent.
- The progressive differentiation and mapping of distinct cell lineages from a
common primordium involves a series of developmental decisions and inductive interactions
The phenotype development of the cell lineages occur as the result of a complex synergistic
or competitive regulation among numerous factors inducing or inhibiting the expression of genes.
The purpose of this long-term investigating is to charaterize the ontogenetic mechanisms
of cell phenotypes, patterning responsiveness to signal and molecular clock regulation in vivo embryo development or in vitro
- The neuron, endocrine, immune and circulatory cells are specificated cell
patterns derived from ectoderm, endoderm and mesoderm of animal embryo. Among these cells have specific
receptors for cell communicating and signal transduction. The cells are organized in spatiotemporal pattern
of developing which regulated by secretory
rhythm of signals and genomic program expression of genes.
The developing patterns of main, collateral channels (Chinese Traditional
Medicine) are the cross signaling through the immune, neuro-endocrine systems, and
take active roles in the psychsomatic regulation of morphogenesis.
An efficient approach, termed sequence
tagged fragments display (STFD), be developed that allow for the identification
of genes from differential expression tissues. Genes origined in the patterns of genes families, and
proteins in structure types. There are many sequence tagged sites on the genes map. These known
sequence or conserved sequence sites can be used for cloning and analysis of genes by transgenic
tagging and ploymerase chain reaction (PCR). The transgenic system includes recipient cell, vector,
gene transfer and embryo manipulation. In the natural and artificial evolution of organisim, the
transgenesis, genetic crossover, mobile element transposon have deleterious effects
and transmission unstability of genome during the coadaption of genes.
The mutagenesis and expression of gene has great potential improving the studying of
the regulation of multiple signals in the developing of cell fate determination and
the genetic patterns of morphogenesis. The goal of the project is useing
transgenic animal models, gene transfection or mutagenesis, stem cells differentiation in vitro to chracterize the
genes and signal transduction pathways involoved in the regulation of cell proliferation, differentiation,
apoptosis and organogenesis.