SYNTHETIC BIOSYSTEMS: BIOREACTOR AND BIO-COMPUTER

 

Bangzhe(Jie) Zeng

Benjoe Institute of System Bio-Engineering, Changzhou 213022, China

 

 

Abstracts:

At the early of the 21 century, systems bioscience is developing very fast as integrative discipline of bio-systems and nano-computer science for exploring of genomic intelligence and artificial bio-systems, since the concepts of systematic psychology (Titchener E.B. 1929), system biomedicine (Kamada T.1992), systems biology (Zieglgansberger W, Tolle TR.1993), system bioengineering (Zeng B.J. 1994), system genetics (Zeng B.J. 1994) and synthetic biology (Hobom B. 1980, Kool E.2000) were introduced.

Systems genetics is investigated on the field of organism’s phenotype – genomic genotype complexity which involved signal transduction, gene regulatory networks of the non-linear cell dynamics of cell fate determination, cytogenesis and cell lineages mapping during structure – pattern formation of biosystem. Synthetic biology is defined as systems biology-based engineering or systems genetic engineering and investigated on artificial designing, integrative synthesis of structure of gene, protein, signal transduction pathway, gene regulatory network, metabolism reaction chain, genome and cell lineage for artificial designed biosystems. Biosystem analytics and biosystem technology can be applied in transgenic bioreactor (avian oviduct, herb metabolism), cell signalling (gene cloning, medical screen) and neuron computer (gene computation, cell auto-machine) etc. Systems biological engineering includes transgenic organism, nano-biotechnology of biosensors, bio-molecular computer and bionic nano-machine etc. Using of computer aid re-design, transgenesis of genes network, engineering of metabolism and re-program of cell, artificial biosystems can be produced for drug bio-manufacture and nano bio-computer.

 

Key words: bioreactor  nano bio-computer  cellron  artificial designed biosystem  non-reproductive organism

 

 

合成生命系统:生物反应器与生物计算机

 

曾(杰)邦哲

邦哲系统生物工程研究所,中国常州,邮编213022

 

 

摘要:

    自从系统心理学(Titchener E.B.1929)、系统生物医学(Kamada T.1992)、系统生物学(Zieglgansberger W, Tolle TR.1993)、系统生物工程学(Zeng B.J.1994)、系统遗传学(Zeng B.J.1994)与合成生物学(Hobom B. 1980, Kool E.2000)的概念形成后,21世纪伊始,探索基因组智能与人工生命系统的生物系统、纳米计算机科学的整合学科 - 系统生物科学飞速发展。

    系统遗传学研究基因组与生物体、基因型与表现型的复杂生物系统结构、图式发生,信号传导、基因网络调控细胞命运决定、细胞系发生、细胞系图谱定位的非线性系统动力学过程。合成生物学是基于系统生物学的应用,开发人工设计生命系统的基因与蛋白质分子、基因调控网络、基因组、信号传导路径、代谢链与细胞结构的设计、综合集成的系统遗传工程。生物系统分析学与生物系统技术,可以应用于转基因生物反应器(禽类输卵管、天然药物)、信号传导检测(基因克隆、临床检验)、神经计算机(基因计算、细胞纳米机器)等。系统生物工程,包括转基因生物、传感器纳米生物技术、生物分子计算和仿生纳米机器等。采用计算机辅助设计、转基因网络、次生代谢工程与细胞程序重编,可以制造人工生物系统用作生物制药厂和纳米生物计算机。

 

关键词:生物反应器 纳米生物计算机 元细胞 人工设计生命 非繁殖生物体

 

 

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Structurity Bulletin, Sept. 6, 2008结构论通报》,200896日)

 

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