Bangzhe J. Zeng

Preface: The Positive and Synthetic Thoughts of Organisms
Eternal Cosmos and Changing of Systems
1. Ontology of Systems Structure
1.1 Substance Entity Structure: Entity, Develop, Exist Axioms; Pan-stability, Pan-interacting, Pan-structure Pricinples;
1.2 Mendal Symbol Structure: Pan-relation, Pan-organism, Pan-inertia Pricinples;
1.3. Concepts, Principles of Structurity: Structure Tolerance, Adaptation, Fluctuation, Interweave, Transform Theorems
2. Creatism of Construct Mutation
2.1 Interaction and Structure Stratificate: Solitary Stratum "+","-"Transfer Make Interaction Match Structure Stratum;
2.2 Mutation, Transmit of Interaction: Same Stratum Systems Interacting Transfer to Other Stratum, Systems Interacting in These Ways: Open, Close, Cycle;
2.3 Structure Stability Pattern: Diamond, Snow & C60Structure stability Based on Tetrahedron Structure (Four Color), C1/4+2C2/4+C3/4, C1/4+6(C2/4+C3/4).
3. Simi-Structure Hologram Organism
3.1 Development of Systems: Object, Motion, Change System Structure, Fuction, Developing, Intergate. Self-construct Body Develop from Subsystem to Suprasystem Structure Transference: No-growth Inner Contracting Make Solidity, Fluid Alternation Sphere Structure; Growth Assimilate Make Fractal Structure
3.2 Hologram of Structure: Developing Model, Cosmos and Brain is Time, Space Fractal Structure. Any Object is Simi-structure from Subsystem to the Suprasystem;
3.3 Structure Logic: Syntax Maded of Vi.t., Aj.v, Nc.u, P(C), Cosmos-Substance, Life, Mentality, Culture-Science, Arts, Religion, Structurity Laws: Integration ("O"), Adaptation("S"), Construction("V").
3.4. Unification and Creation
S+I=Constant, Eternal Interation, Asymmetry Stable and Mutation Split, Changable Creatism of Cosmos.

PART II. LIFE SYSTEMS: Pattern (System) Genetics
Biosystem is the morphogenesis system of structure complement each other and structification, functional couple and interflow bounds growth, cordinative transformation and holographic symmetry. Genetics be explored the relation of phenotype with genotype (Mendelian Genetics); regulation of gene expression (Molecular Genetics); and the structural evolution of genomes, unified theory of heredity, development and evolution (Structural/System Genetics).
1. The Logic of Organisms Structure
1.1. The Origin of Life System: Cell Origin and Regulation of Cell Metabolism, Ai+A0->Aj+A(i+1), Aj->A0. Proteins groups and molecules interaction of essential biochemical system in original cell, adapted in cell species, and induced in tissue cells. The metabolism systems of organelles, Intra membrane apparatus, movetive skeleton, intracell and intercells signals.
1.2. Structure of Holographic Reenact: The logic of self-renew, self-duplicated, self-regulated, self-adaptated information control system, C0->Ci+Cj->C(i+1)+C0.
1.3. Organization of Genome
Genetic and Physical Gene Mapping: Genomic and cDNA maps, compare the genes organization in genome with the expression pattern of proteins.
2. Program Expression of Genes
Morphogenesis and Adaptative Development:
2.1. Regulation of Gene Expression and Protein Degradation:
The regulate and structural elements in gene for specific expression and function of proteins; Gene transcription, mRNA localisation; Proteins translation, fold, targeting and degradation; The assemble and degradation of cell compartments;
2.2. Cell Mitotic, Differentiation and Prolification, apoptosis.
Signal molecules interacelluar asymmetry, duplication of cell genome and tissue specificial expression of genes by genomic program, Specific induce expression and differentiation in vitro;
2.3. Oscillation and Patterning:
The tissue cells be constructed in coherent body: Cell cycle and fate be controled by secretory (neurohumoral) rhythms of signals. The regulatory pattern of neuron, immune and endocrine, circulatory cells developed from ectoderm, endoderm and mesoderm of embryo. The notochord of head and trunk inductors, double gradient signal regulation, coordanative movement of embryo cells groups.
2.4. Pharmacognacy, Psychosomatic Medicine:
The stimualation pattern of experience strengthen specfic connections among neurons, specific protein biosysthesis.
3. Cellular Mutation and Evolution of Organisms:
Self-Organization Co-evulotion: The natural and artificial evolution (amplification, rearrangment and transposon) of genes in genome.
3.1. Replication and Homologous Recombination:
Genetic crossover, genes rearrangment in duplication, mutation and repair of DNA;
3.2. The Mobile Elements of Gene:
Virus, cancer genes transposon causes cells mutation of genes in genome, Gene target and homologous recombination;
3.3. Multify Stratum Construction in Genome:
Intereacting among genes in host and the genetic coadaptation, Genes group, genes family and genes chain in the multify stratum construction of genome from prokaryocyte, eukaryocyte to multicells organism.
3.4. Laws of Genetic Structurity
Structurity (Pattern) Genetics: the genetics and bio-logic of the molecular, cellular and organisim patterning; the structure (organization), function ( development, specific expression) and mutantion (evolution, self-organization) of genomes.
1.) Structure Integration:
Cordinative organization of genes in genome, the independent phenotype is controlled by genes group (multigenes);
2.) Function Adaptation:
Duplication (amplify) of cell genome, tissue-specific expression of genes, the expression of genes chain depends on the self-adaptation in signals field of the cell microenvironment;
3.) Construct Stratification:
Recombination, multiple stratum structure of genome, the mutation in genes family of gene transpose, recombination and amplification.

1. Brain Transform System:
1.1 Artificial Society: Bi+B0->Bj, Bj+B0->Bi+1.
1.2 Regulation of Culture Structure: Economic Development, Bio-logic Society.
2. Artificial Evolution of Biosystems:
Biosystems Analytics, Informatics, Transgenics, Bionics, Genomics and Bioethnics. Bioengineering inludes the bionics of biosystem, transgenic organisms and ecological engineering.
2.1 Transgenic Organisms
From Genomic DNA & cDNA library, gene mapping, isolation & cloning to gene expression, transgenesis. 1.) Transgenic system includes gene synthesis, sequence and plasmid & virus vectors construction, transformation with Bacteria, recepte cell and tissue culture, gene transfection (sperm cell, microinject, gene gun, virus transfer and ES cell, transposor intergrate methods), cell fuse & nuclei, embryo transfer, specific induce expression & selection screen. 2.) The Applications of Transgensis: to change genome by insert into or knock out be used for manufact products (bioreactor, organs transplantation), genetic improvement (organism breeding, gene therapy) and research methods (disease models, gene regulation).
2.2 Bionic Engineering
1.) Biomolecular Computation: Artificial life, genetic logic of self-organization.
2.) Biochips: Bionic machines, intelligence robot.
3. Culture Evolution and Human in Future
The Time of Biosystem Science and Engineering.
3.1 Evolution of Culture
3.2 Artificial Biosystems
Future world of human will be cultural evulotion system of machine and organism integrated. The R & D of artificial organism, intelligence robot are the high technology of human economics and industrials.
Forward: Classified Knowlege Systems of Human
1. Molecular Cell, Organ Morphogenesis.
2. Cells Evolution and Organization.
3. Signals in Genes Program Expression.
4. Cells Mapping of Organism Pattern.
5. Transgenic Bird Oviduct Bioreactor.
6. Structure of Sciences System.
1. Brief History of Genetic Science and Technology
2. Lists of Biotechnology, Bioinformatics Companies

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(All rights reserved SysBioEng, please cite as:
Bangzhe J. Zeng (BenJoe Tseng), Structurity - Panevolution Theory (Biosystem Medicine - Psychosomatics Thesis, 1986-1993), press in Changsha May 1994, online by Structurity Bulletin 1999)

(Full Text in Chinese & Web Translation)

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