Pattern (System) Genetics:
Signaling regulation of cells proliferation, differentiation
and apotosis in organism patterning, and the patterns of genes organization, genomic program expression and
evolutionary morphogenetics of biosystem (Pattern/Module).
There are essential metabloism sytems and housekeep genes expression, induced expression for adaptation and tissuse specificial expression of genes in program. There are feedback regulations between different metabolism pathways of molecules.
The regulation of expression depend on the elements in the sequence of gene, the promotor for transciption regulation, the untranslated region of mRNA for regulation of mRNA stability and translation, the membrane domain for protein degradation. There are signal molecules for regulation at multiple levels.
Morphogenesis of organs depends on the cell fate determination in the proferation, differentiation or apotosis through different signal transduction pathways, patterns of secretary signalling. Signal communicating among the different tissue cells.
The genes replication, transcription, fragmentation, mutagenesis and the biomolecules interacting are the dynamics of genomic information system. Between genes in allele or among linear locus, there are expression patterns of development and evolution.