.PATTERN GENETICS.

Structurity: Pan-Evolution Theory
The Vascular and Neuro-endocrine Pattern in Morphogenesis

B. J. Zeng

ABSTRACTS:

Organism is morphogenetic system which components complete each other to structure stratification, interflow bounds growth by functional couple, coordinative organization transform as holographic symmetry. Biosystems are self-renew, self-duplication, self-regulation, and self-adaption information control systems which are dynamically regulated by the genomic organizing pattern, developmental function and evolutional mutagenesis.
During the embryo morphogenesis, the pattern of body construction involves a series of genes expression in primordium modules developing and cell lineages differentiation in organogenesis. We draw attention to the cross talking and cells communication among neuron, endocrine and immune systems, and the vascular developing patterns. In Traditional Chinese Medicine (TCM), the main and collateral channels are the functional integrative systems of neuro-endocrine, immune and circulatory regulation. The psychosomatic regulation and genetic pattern play bidirectional control roles on pathogenesis of human organism. The organogenesis pattern involve a series of signals which regulate the cell division, differentiation and the mapping of cells lineages. The organizing of cells mapping is regulated by the program expression of signal transmission patterns. The cell phenotypes developing occur as the result of a complex spatiotemporal genes expression among numerous factors controlling.
The cardiovascular diseases most like lost control of cell cycle, rhythmical regulation and gene expression involved in the metabolism, vascular function and cell differentiation, proliferation. We were investigating the mechanism that control the pathogenesis and morphogenesis patterns of vascular systems, and the pharmacognacy effects on the metabolism involved in memory function. We characterized novel relationships of the main, collateral channels among organs (TCM), obtained successfully the drug resistant cellular mutants by multiple steps mutagenesis, and developed a novel pharmacy for improvement of memory function and the synthetic therapy of the complex cardiovascular diseases.
The homeostasis or dynamics of molecules synthesis between degradation, cells proliferation between apoptosis which involve the replication, fragmentation, recombination and expression of gene. In the natural evolution, cells were self-organized in genomic patterns. The genomic stratification is the self-organization of gene families, gene groups and gene chains. The pattern (system - structure) genetics includes the follow three main aspects.
I ). Structure integration- coordinative organization of genes in genomic stratum. The independent organism phenotype is controlled by synergic expression of gene group (multigenes), and this phenotype forms a functional or morphogenesis unit (module). Each specie has it's unique structure of genomic organizing pattern among chromosomes by the constructing of genomic stability during evolution of genetic co-adaptation. From elements of gene, operon, gene group to chromosome, they are the multiple levels of structural patterns of genome. The biochemical metabolism systems include the essential systems in original cells, adaptation systems in cell species, and program induced expression systems in tissue cells such as the neuron, endocrine, immune and vascular cells etc.
II ). Functional adaptation- program expression of organism phenotypes: a). structure duplication (amplify) of cell genome, b). tissue-specific expression of genes. The sequential expression of genes chain in genomic program involves the interaction among locus of genes in chromosome, molecules network within cell and signal communication between cells. The patterns of neuron, endocrine, immune and vascular cell types which develop from ectoderm, endoderm and mesoderm of embryo. These cells have specific receptors, signal molecules for cell communication at bidirectional.
In mammalian embryo, the notochord which developed from grey crescent of organizer, the double gradient of head and trunk signals, the stem cell producing center and the neuro-endocine, immune system play roles in the control of morphogenesis at multiple levels. The connection of neural networks occur as the result of cell recognition and specific protein biosynthesis. The stimulating pattern of learning experience strengthen specific connections among neurons. The cell phenotypes expression and mapping of cells fate determination in organogenesis involves a series of genes spatially and temporally expression by genomic program. The stable rhythm patterns of secretary molecules regulate gene expression in bio-molecules synthesis, degradation and cells differentiation, proliferation and apoptosis.
III ). Stratified (Mutation) construction- self-organization of genomes in evolution: a). recombinant at same level of structure- the homologous recombination, genes rearrangement in the genetic crossover, transpose of mobile elements; b). multiple stratum structure of gene groups at different levels; c). mutation in gene families: gene family origin from the series of mutations in gene duplication. The evolution of biological species origin from the stratum constructing of genomes. The main evolution pathway of organisms is the evolution from prokaryocyte, eukaryocyte to multiple cells organism.
The recombination (genetic crossover, mobile elements transpose), transgenesis and amplification of genes are the dynamic procedures of genome. The artificial evolution includes the engineering evolution of biosystems by genetic and bionic engineering. The transgenesis in genome has be allowed to used for manufacture products (bioreactor, xenotransplantation), genetic improvement (organism breeding, gene therapy) and research methods (disease models, gene regulation). However, the transgenes have deleterious effects, transmission un-stability of genome. The isolation of embryonic stem (ES) cells, primordial germ cells (PGC), formation of chimeras from reimplanting embryo by gene targeted ES cells injection are important tools for the study of cell program differentiation, pattern of morphogenesis and pathogenesis of diseases.
The pattern genetics is the science to study the complex pattern relationship between phenotype and genotype, the genes expression network of genomic program, the bio-logic principles of biosystems and the organizing patterns of genomes. The genetic program controls the genotype developing into phenotype, genes expression into functional proteins, modules constructing to the pattern of in morphogenesis. The morphogenesis of biosystems which include molecules, cell types, organs and organisms, involves a series of metabolism, molecular signals and genes regulated expression in the cell division, differentiation and patterning of vascular, neuro-endocrine and immune systems.

Please cite as:
B. J. Zeng, "Structurity: Pan-Evolution Theory" (Biosystem Medicine - Psychosomatics Thesis, 1986-1993, 1994), Structurity Bulletin 1999.

Structurity Bulletin